To build a successful one-product Shopify store, follow these steps: 1. Choose a unique, high-quality product that meets a specific need or demand in your target market, 2. Set up your Shopify store and choose a visually appealing, user-friendly theme that highlights your product's features and benefits, 3. Create engaging, informative content to showcase your product, such as high-quality images, videos, and text, 4. Develop a comprehensive marketing strategy to drive targeted traffic to your store, utilizing channels like social media, email marketing, and search engine optimization, 5. Provide exceptional customer support and communication to ensure customer satisfaction and foster brand loyalty, and 6. Monitor your store's performance using analytics tools and adjust your strategies as needed to optimize your store's success.